OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Organic cation transporter 1, OCT1 (SLC22A1), is the major hepatic uptake transporter for metformin, the most prescribed antidiabetic drug. However, its endogenous role is poorly understood. Here we show that similar to metformin treatment, loss of Oct1 caused an increase in the ratio of AMP to ATP,...

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Detalhes bibliográficos
Main Authors: Chen, Ligong, Shu, Yan, Liang, Xiaomin, Chen, Eugene C., Yee, Sook Wah, Zur, Arik A., Li, Shuanglian, Xu, Lu, Keshari, Kayvan R., Lin, Michael J., Chien, Huan-Chieh, Zhang, Youcai, Morrissey, Kari M., Liu, Jason, Ostrem, Jonathan, Younger, Noah S., Kurhanewicz, John, Shokat, Kevan M., Ashrafi, Kaveh, Giacomini, Kathleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103324/
https://ncbi.nlm.nih.gov/pubmed/24961373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314939111
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