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LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates
Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood-brain barrier (BBB) that offers the potential to deliver drugs to the brain. It is also up-regulated in cancer cells, as part of a tumor’s increased metabolic demands. Previously, amino acid prod...
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| Veröffentlicht in: | Bioorg Med Chem Lett |
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| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5076878/ https://ncbi.nlm.nih.gov/pubmed/27624080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.09.001 |
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