LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood-brain barrier (BBB) that offers the potential to deliver drugs to the brain. It is also up-regulated in cancer cells, as part of a tumor’s increased metabolic demands. Previously, amino acid prod...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Zur, Arik A., Chien, Huan-Chieh, Augustyn, Evan, Flint, Andrew, Heeren, Nathan, Finke, Karissa, Hernandez, Christopher, Hansen, Logan, Miller, Sydney, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076878/
https://ncbi.nlm.nih.gov/pubmed/27624080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.09.001
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