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Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

The Large-neutral Amino Acid Transporter 1 (LAT-1)—a sodium-independent exchanger of amino acids, thyroid hormones, and prescription drugs—is highly expressed in the blood–brain barrier and various types of cancer. LAT-1 plays an important role in cancer development as well as in mediating drug and...

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Bibliografiska uppgifter
Huvudupphovsmän: Geier, Ethan G., Schlessinger, Avner, Fan, Hao, Gable, Jonathan E., Irwin, John J., Sali, Andrej, Giacomini, Kathleen M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619328/
https://ncbi.nlm.nih.gov/pubmed/23509259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218165110
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