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Prediction and validation of enzyme and transporter off-targets for metformin
Metformin, an established first-line treatment for patients with type 2 diabetes, has been associated with gastrointestinal (GI) adverse effects that limit its use. Histamine and serotonin have potent effects on the GI tract. The effects of metformin on histamine and serotonin uptake were evaluated...
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| Publicado no: | J Pharmacokinet Pharmacodyn |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4656030/ https://ncbi.nlm.nih.gov/pubmed/26335661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-015-9436-y |
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