Prediction and validation of enzyme and transporter off-targets for metformin

Metformin, an established first-line treatment for patients with type 2 diabetes, has been associated with gastrointestinal (GI) adverse effects that limit its use. Histamine and serotonin have potent effects on the GI tract. The effects of metformin on histamine and serotonin uptake were evaluated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacokinet Pharmacodyn
Prif Awduron: Yee, Sook Wah, Lin, Lawrence, Merski, Matthew, Keiser, Michael J., Gupta, Aakash, Zhang, Youcai, Chien, Huan-Chieh, Shoichet, Brian K., Giacomini, Kathleen M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656030/
https://ncbi.nlm.nih.gov/pubmed/26335661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-015-9436-y
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