Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Por Zake, Darta Maija, Kurlovics, Janis, Zaharenko, Linda, Komasilovs, Vitalijs, Klovins, Janis, Stalidzans, Egils
Publicado no PLoS One (2021)

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Por Rovite, Vita, Wolff-Sagi, Yael, Zaharenko, Linda, Nikitina-Zake, Liene, Grens, Elmars, Klovins, Janis
Publicado no J Epidemiol (2018)

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Por Ustinova, Monta, Peculis, Raitis, Rescenko, Raimonds, Rovite, Vita, Zaharenko, Linda, Elbere, Ilze, Silamikele, Laila, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis
Publicado no BMC Med Genomics (2021)

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Por Elbere, Ilze, Kalnina, Ineta, Silamikelis, Ivars, Konrade, Ilze, Zaharenko, Linda, Sekace, Kristine, Radovica-Spalvina, Ilze, Fridmanis, Davids, Gudra, Dita, Pirags, Valdis, Klovins, Janis
Publicado no PLoS One (2018)

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Por Elbere, Ilze, Silamikelis, Ivars, Dindune, Ilze Izabella, Kalnina, Ineta, Ustinova, Monta, Zaharenko, Linda, Silamikele, Laila, Rovite, Vita, Gudra, Dita, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis
Publicado no PLoS One (2020)

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Por Elbere, Ilze, Silamikelis, Ivars, Ustinova, Monta, Kalnina, Ineta, Zaharenko, Linda, Peculis, Raitis, Konrade, Ilze, Ciuculete, Diana Maria, Zhukovsky, Christina, Gudra, Dita, Radovica-Spalvina, Ilze, Fridmanis, Davids, Pirags, Valdis, Schiöth, Helgi B., Klovins, Janis
Publicado no Clin Epigenetics (2018)

Extending the Minimum Information About BIobank Data Sharing Terminology to Describe Samples, Sample Donors, and Events

Por Eklund, Niina, Andrianarisoa, Ny Haingo, van Enckevort, Esther, Anton, Gabriele, Debucquoy, Annelies, Müller, Heimo, Zaharenko, Linda, Engels, Cäcilia, Ebert, Lars, Neumann, Michael, Geeraert, Joachim, T'Joen, Veronique, Demski, Hans, Caboux, Élodie, Proynova, Rumyana, Parodi, Barbara, Mate, Sebastian, van Iperen, Erik, Merino-Martinez, Roxana, Quinlan, Philip R., Holub, Petr, Silander, Kaisa
Publicado no Biopreserv Biobank (2020)

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research

Por Spjuth, Ola, Krestyaninova, Maria, Hastings, Janna, Shen, Huei-Yi, Heikkinen, Jani, Waldenberger, Melanie, Langhammer, Arnulf, Ladenvall, Claes, Esko, Tõnu, Persson, Mats-Åke, Heggland, Jon, Dietrich, Joern, Ose, Sandra, Gieger, Christian, Ried, Janina S, Peters, Annette, Fortier, Isabel, de Geus, Eco JC, Klovins, Janis, Zaharenko, Linda, Willemsen, Gonneke, Hottenga, Jouke-Jan, Litton, Jan-Eric, Karvanen, Juha, Boomsma, Dorret I, Groop, Leif, Rung, Johan, Palmgren, Juni, Pedersen, Nancy L, McCarthy, Mark I, van Duijn, Cornelia M, Hveem, Kristian, Metspalu, Andres, Ripatti, Samuli, Prokopenko, Inga, Harris, Jennifer R
Publicado no Eur J Hum Genet (2016)

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Por Zhou, Kaixin, Yee, Sook Wah, Seiser, Eric L, van Leeuwen, Nienke, Tavendale, Roger, Bennett, Amanda J, Groves, Christopher J, Coleman, Ruth L, van der Heijden, Amber A, Beulens, Joline W, de Keyser, Catherine E, Zaharenko, Linda, Rotroff, Daniel M, Out, Mattijs, Jablonski, Kathleen A, Chen, Ling, Javorský, Martin, Židzik, Jozef, Levin, Albert M, Williams, L Keoki, Dujic, Tanja, Semiz, Sabina, Kubo, Michiaki, Chien, Huan-Chieh, Maeda, Shiro, Witte, John S, Wu, Longyang, Tkáč, Ivan, Kooy, Adriaan, van Schaik, Ron H N, Stehouwer, Coen D A, Logie, Lisa, Sutherland, Calum, Klovins, Janis, Pirags, Valdis, Hofman, Albert, Stricker, Bruno H, Motsinger-Reif, Alison A, Wagner, Michael J, Innocenti, Federico, 't Hart, Leen M, Holman, Rury R, McCarthy, Mark I, Hedderson, Monique M, Palmer, Colin N A, Florez, Jose C, Giacomini, Kathleen M, Pearson, Ewan R
Publicado no Nat Genet (2016)