A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

Autor McQuaker, Stephen J, Quinlan, Casey L, Caldwell, Stuart T, Brand, Martin D, Hartley, Richard C
Vydáno 2013

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

Autor Caldwell, Stuart T., Cairns, Andrew G., Olson, Marnie, Chalmers, Susan, Sandison, Mairi, Mullen, William, McCarron, John G., Hartley, Richard C.
Vydáno v Tetrahedron (2015)

Photoactivated release of membrane impermeant sulfonates inside cells

Autor Caldwell, Stuart T., O'Byrne, Sean N., Wilson, Calum, Cvetko, Filip, Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Vydáno v Chem Commun (Camb) (2021)

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo

Autor Burger, Nils, Logan, Angela, Prime, Tracy A., Mottahedin, Amin, Caldwell, Stuart T., Krieg, Thomas, Hartley, Richard C., James, Andrew M., Murphy, Michael P.
Vydáno v Free Radic Biol Med (2020)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

Autor Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Vydáno v J Biol Chem (2020)

Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase

Autor Cao, Zhenbo, Mitchell, Lorna, Hsia, Oliver, Scarpa, Miriam, Caldwell, Stuart T., Alfred, Arina D., Gennaris, Alexandra, Collet, Jean-François, Hartley, Richard C., Bulleid, Neil J.
Vydáno v Biochem J (2018)

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

Autor Chalmers, Susan, Caldwell, Stuart T., Quin, Caroline, Prime, Tracy A., James, Andrew M., Cairns, Andrew G., Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Vydáno 2011

Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

Autor Pala, Laura, Senn, Hans M., Caldwell, Stuart T., Prime, Tracy A., Warrington, Stefan, Bright, Thomas P., Prag, Hiran A., Wilson, Claire, Murphy, Michael P., Hartley, Richard C.
Vydáno v Front Chem (2020)

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

Autor Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T., Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Vydáno v Mol Pharm (2020)

Tetra-arylborate lipophilic anions as targeting groups

Autor Gaddale Devanna, Kishore K., Gawel, Justyna M., Prime, Tracy A., Cvetko, Filip, Benincá, Cristiane, Caldwell, Stuart T., Negoda, Alexander, Harrison, Andrew, James, Andrew M., Pavlov, Evgeny V., Murphy, Michael P., Hartley, Richard C.
Vydáno v Chem Commun (Camb) (2021)

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Autor Fazakerley, Daniel J., Minard, Annabel Y., Krycer, James R., Thomas, Kristen C., Stöckli, Jacqueline, Harney, Dylan. J., Burchfield, James G., Maghzal, Ghassan J., Caldwell, Stuart T., Hartley, Richard C., Stocker, Roland, Murphy, Michael P., James, David E.
Vydáno v J Biol Chem (2018)

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis

Autor Antonucci, Salvatore, Mulvey, John F., Burger, Nils, Di Sante, Moises, Hall, Andrew R., Hinchy, Elizabeth C., Caldwell, Stuart T., Gruszczyk, Anja V., Deshwal, Soni, Hartley, Richard C., Kaludercic, Nina, Murphy, Michael P., Di Lisa, Fabio, Krieg, Thomas
Vydáno v Free Radic Biol Med (2019)

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Autor Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Vydáno v Cardiovasc Drugs Ther (2019)

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Autor Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Vydáno v Cardiovasc Drugs Ther (2020)

Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide

Autor Tan, Sih Min, Lindblom, Runa S. J., Ziemann, Mark, Laskowski, Adrienne, Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, El-Osta, Assam, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Cooper, Mark E., Murphy, Michael P., Coughlan, Melinda T.
Vydáno v Nutrients (2021)

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

Autor Booty, Lee M., Gawel, Justyna M., Cvetko, Filip, Caldwell, Stuart T., Hall, Andrew R., Mulvey, John F., James, Andrew M., Hinchy, Elizabeth C., Prime, Tracy A., Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P., Clatworthy, Menna R., Ferdinand, John R., Prag, Hiran A., Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Vydáno v Cell Chem Biol (2019)

MitoNeoD: A Mitochondria-Targeted Superoxide Probe

Autor Shchepinova, Maria M., Cairns, Andrew G., Prime, Tracy A., Logan, Angela, James, Andrew M., Hall, Andrew R., Vidoni, Sara, Arndt, Sabine, Caldwell, Stuart T., Prag, Hiran A., Pell, Victoria R., Krieg, Thomas, Mulvey, John F., Yadav, Pooja, Cobley, James N., Bright, Thomas P., Senn, Hans M., Anderson, Robert F., Murphy, Michael P., Hartley, Richard C.
Vydáno v Cell Chem Biol (2017)

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

Autor Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Vydáno v Nat Metab (2019)

Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart

Autor Park, Min, Nishimura, Takanori, Baeza-Garza, Carlos D., Caldwell, Stuart T., Pun, Pamela Boon Li, Prag, Hiran A., Young, Tim, Sauchanka, Olga, Logan, Angela, Forkink, Marleen, Gruszczyk, Anja V., Prime, Tracy A., Arndt, Sabine, Naudi, Alba, Pamplona, Reinald, Coughlan, Melinda T., Tate, Mitchel, Ritchie, Rebecca H., Caicci, Federico, Kaludercic, Nina, Di Lisa, Fabio, Smith, Robin A. J., Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Vydáno v Cardiovasc Drugs Ther (2020)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Autor Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.
Vydáno v Nature (2018)