The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

PURPOSE: Methylglyoxal, a by-product of glycolysis and a precursor in the formation of advanced glycation end-products, is significantly elevated in the diabetic myocardium. Therefore, we sought to investigate the mitochondria-targeted methylglyoxal scavenger, MitoGamide, in an experimental model of...

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Vydáno v:Cardiovasc Drugs Ther
Hlavní autoři: Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2019
Témata:
Short Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994445/
https://ncbi.nlm.nih.gov/pubmed/31654171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-019-06914-9
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