A Prototypical Small-Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production

Por McQuaker, Stephen J, Quinlan, Casey L, Caldwell, Stuart T, Brand, Martin D, Hartley, Richard C
Publicado em 2013

Synthesis of an azido-tagged low affinity ratiometric calcium sensor

Por Caldwell, Stuart T., Cairns, Andrew G., Olson, Marnie, Chalmers, Susan, Sandison, Mairi, Mullen, William, McCarron, John G., Hartley, Richard C.
Publicado no Tetrahedron (2015)

Photoactivated release of membrane impermeant sulfonates inside cells

Por Caldwell, Stuart T., O'Byrne, Sean N., Wilson, Calum, Cvetko, Filip, Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Publicado no Chem Commun (Camb) (2021)

A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo

Por Burger, Nils, Logan, Angela, Prime, Tracy A., Mottahedin, Amin, Caldwell, Stuart T., Krieg, Thomas, Hartley, Richard C., James, Andrew M., Murphy, Michael P.
Publicado no Free Radic Biol Med (2020)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

Por Cvetko, Filip, Caldwell, Stuart T., Higgins, Maureen, Suzuki, Takafumi, Yamamoto, Masayuki, Prag, Hiran A., Hartley, Richard C., Dinkova-Kostova, Albena T., Murphy, Michael P.
Publicado no J Biol Chem (2020)

Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase

Por Cao, Zhenbo, Mitchell, Lorna, Hsia, Oliver, Scarpa, Miriam, Caldwell, Stuart T., Alfred, Arina D., Gennaris, Alexandra, Collet, Jean-François, Hartley, Richard C., Bulleid, Neil J.
Publicado no Biochem J (2018)

Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

Por Chalmers, Susan, Caldwell, Stuart T., Quin, Caroline, Prime, Tracy A., James, Andrew M., Cairns, Andrew G., Murphy, Michael P., McCarron, John G., Hartley, Richard C.
Publicado em 2011

Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation

Por Pala, Laura, Senn, Hans M., Caldwell, Stuart T., Prime, Tracy A., Warrington, Stefan, Bright, Thomas P., Prag, Hiran A., Wilson, Claire, Murphy, Michael P., Hartley, Richard C.
Publicado no Front Chem (2020)

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

Por Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T., Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado no Mol Pharm (2020)

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

Por Fazakerley, Daniel J., Minard, Annabel Y., Krycer, James R., Thomas, Kristen C., Stöckli, Jacqueline, Harney, Dylan. J., Burchfield, James G., Maghzal, Ghassan J., Caldwell, Stuart T., Hartley, Richard C., Stocker, Roland, Murphy, Michael P., James, David E.
Publicado no J Biol Chem (2018)

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis

Por Antonucci, Salvatore, Mulvey, John F., Burger, Nils, Di Sante, Moises, Hall, Andrew R., Hinchy, Elizabeth C., Caldwell, Stuart T., Gruszczyk, Anja V., Deshwal, Soni, Hartley, Richard C., Kaludercic, Nina, Murphy, Michael P., Di Lisa, Fabio, Krieg, Thomas
Publicado no Free Radic Biol Med (2019)

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Por Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Publicado no Cardiovasc Drugs Ther (2019)

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Por Tate, Mitchel, Higgins, Gavin C., De Blasio, Miles J., Lindblom, Runa, Prakoso, Darnel, Deo, Minh, Kiriazis, Helen, Park, Min, Baeza-Garza, Carlos D., Caldwell, Stuart T., Hartley, Richard C., Krieg, Thomas, Murphy, Michael P., Coughlan, Melinda T., Ritchie, Rebecca H.
Publicado no Cardiovasc Drugs Ther (2020)

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo

Por Booty, Lee M., Gawel, Justyna M., Cvetko, Filip, Caldwell, Stuart T., Hall, Andrew R., Mulvey, John F., James, Andrew M., Hinchy, Elizabeth C., Prime, Tracy A., Arndt, Sabine, Beninca, Cristiane, Bright, Thomas P., Clatworthy, Menna R., Ferdinand, John R., Prag, Hiran A., Logan, Angela, Prudent, Julien, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Publicado no Cell Chem Biol (2019)

MitoNeoD: A Mitochondria-Targeted Superoxide Probe

Por Shchepinova, Maria M., Cairns, Andrew G., Prime, Tracy A., Logan, Angela, James, Andrew M., Hall, Andrew R., Vidoni, Sara, Arndt, Sabine, Caldwell, Stuart T., Prag, Hiran A., Pell, Victoria R., Krieg, Thomas, Mulvey, John F., Yadav, Pooja, Cobley, James N., Bright, Thomas P., Senn, Hans M., Anderson, Robert F., Murphy, Michael P., Hartley, Richard C.
Publicado no Cell Chem Biol (2017)

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation

Por Martin, Jack L., Costa, Ana S. H., Gruszczyk, Anja V., Beach, Timothy E., Allen, Fay M., Prag, Hiran A., Hinchy, Elizabeth C., Mahbubani, Krishnaa, Hamed, Mazin, Tronci, Laura, Nikitopoulou, Efterpi, James, Andrew M., Krieg, Thomas, Robinson, Alan J., Huang, Margaret H., Caldwell, Stuart T., Logan, Angela, Pala, Laura, Hartley, Richard C., Frezza, Christian, Saeb-Parsy, Kourosh, Murphy, Michael P.
Publicado no Nat Metab (2019)

Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart

Por Park, Min, Nishimura, Takanori, Baeza-Garza, Carlos D., Caldwell, Stuart T., Pun, Pamela Boon Li, Prag, Hiran A., Young, Tim, Sauchanka, Olga, Logan, Angela, Forkink, Marleen, Gruszczyk, Anja V., Prime, Tracy A., Arndt, Sabine, Naudi, Alba, Pamplona, Reinald, Coughlan, Melinda T., Tate, Mitchel, Ritchie, Rebecca H., Caicci, Federico, Kaludercic, Nina, Di Lisa, Fabio, Smith, Robin A. J., Hartley, Richard C., Murphy, Michael P., Krieg, Thomas
Publicado no Cardiovasc Drugs Ther (2020)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Por Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.
Publicado no Nature (2018)