APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

著者: Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
出版年 Cell Death Dis (2018)

p53 as a hub in cellular redox regulation and therapeutic target in cancer

著者: Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
出版年 J Mol Cell Biol (2019)

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

著者: Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
出版年 Cell Death Dis (2019)

PRIMA-1(MET) Inhibits Growth of Mouse Tumors Carrying Mutant p53

著者: Zache, Nicole, Lambert, Jeremy M. R., Wiman, Klas G., Bykov, Vladimir J. N.
出版年 Cell Oncol (2008)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

著者: Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
出版年 Front Oncol (2016)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

著者: Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
出版年 Front Oncol (2018)

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

著者: Synnott, Naoise C., Madden, Stephen F., Bykov, Vladimir J.N., Crown, John, Wiman, Klas G., Duffy, Michael J.
出版年 Transl Oncol (2018)

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

著者: Bykov, Vladimir J. N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
出版年 J Biol Chem (2017)

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

著者: Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
出版年 Sci Rep (2018)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

著者: Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
出版年 Mol Oncol (2008)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

著者: Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
出版年 Mol Oncol (2017)

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

著者: Shen, Jinfeng, van den Bogaard, Ellen H., Kouwenhoven, Evelyn N., Bykov, Vladimir J. N., Rinne, Tuula, Zhang, Qiang, Tjabringa, Geuranne S., Gilissen, Christian, van Heeringen, Simon J., Schalkwijk, Joost, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing
出版事項 2013

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

著者: Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
出版年 Cell Death Dis (2021)

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

著者: Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
出版年 EMBO Mol Med (2020)