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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277
The TP53 tumor suppressor gene is frequently inactivated in human tumors by missense mutations in the DNA binding domain. TP53 mutations lead to protein unfolding, decreased thermostability and loss of DNA binding and transcription factor function. Pharmacological targeting of mutant p53 to restore...
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| Vydáno v: | Cell Death Dis |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group UK
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5906465/ https://ncbi.nlm.nih.gov/pubmed/29670092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0463-7 |
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