Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle arrest or apoptosis, or regulate cell metabolism, and other processes. Missense mutations in TP53 abolish specific DNA binding of p53 and allow evasion of apoptosis and accele...

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Vydáno v:Front Oncol
Hlavní autoři: Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4737887/
https://ncbi.nlm.nih.gov/pubmed/26870698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00021
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