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p53 as a hub in cellular redox regulation and therapeutic target in cancer

The TP53 tumor suppressor gene encodes a DNA-binding transcription factor that regulates multiple cellular processes including cell growth and cell death. The ability of p53 to bind to DNA and activate transcription is tightly regulated by post-translational modifications and is dependent on a reduc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Mol Cell Biol
Main Authors: Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734141/
https://ncbi.nlm.nih.gov/pubmed/30892598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz005
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