Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been linked to expression of the enzyme asparagine synthetase (ASNS), which generates...

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Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282662/
https://ncbi.nlm.nih.gov/pubmed/34267184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03988-y
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