APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Por Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Publicado no Cell Death Dis (2018)

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Por Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
Publicado no J Mol Cell Biol (2019)

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Por Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Publicado no Cell Death Dis (2019)

PRIMA-1(MET) Inhibits Growth of Mouse Tumors Carrying Mutant p53

Por Zache, Nicole, Lambert, Jeremy M. R., Wiman, Klas G., Bykov, Vladimir J. N.
Publicado no Cell Oncol (2008)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Por Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
Publicado no Front Oncol (2016)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

Por Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
Publicado no Front Oncol (2018)

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

Por Synnott, Naoise C., Madden, Stephen F., Bykov, Vladimir J.N., Crown, John, Wiman, Klas G., Duffy, Michael J.
Publicado no Transl Oncol (2018)

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

Por Bykov, Vladimir J. N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
Publicado no J Biol Chem (2017)

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Por Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
Publicado no Sci Rep (2018)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

Por Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
Publicado no Mol Oncol (2008)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

Por Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
Publicado no Mol Oncol (2017)

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

Por Shen, Jinfeng, van den Bogaard, Ellen H., Kouwenhoven, Evelyn N., Bykov, Vladimir J. N., Rinne, Tuula, Zhang, Qiang, Tjabringa, Geuranne S., Gilissen, Christian, van Heeringen, Simon J., Schalkwijk, Joost, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing
Publicado em 2013

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

Por Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
Publicado no EMBO Mol Med (2020)