APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, e...

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Main Authors: Shen, Jinfeng, van den Bogaard, Ellen H., Kouwenhoven, Evelyn N., Bykov, Vladimir J. N., Rinne, Tuula, Zhang, Qiang, Tjabringa, Geuranne S., Gilissen, Christian, van Heeringen, Simon J., Schalkwijk, Joost, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568378/
https://ncbi.nlm.nih.gov/pubmed/23355676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201993110
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