Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1(Met)) can reactive mutant p53 in tumor cells and trigger cell death by apoptosis. The thioredoxin (Trx) and glutaredoxin (Grx) syst...

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Vydáno v:Sci Rep
Hlavní autoři: Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107631/
https://ncbi.nlm.nih.gov/pubmed/30140002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31048-7
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