APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Autor Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Vydáno v Cell Death Dis (2018)

p53 as a hub in cellular redox regulation and therapeutic target in cancer

Autor Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
Vydáno v J Mol Cell Biol (2019)

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

Autor Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
Vydáno v Cell Death Dis (2019)

PRIMA-1(MET) Inhibits Growth of Mouse Tumors Carrying Mutant p53

Autor Zache, Nicole, Lambert, Jeremy M. R., Wiman, Klas G., Bykov, Vladimir J. N.
Vydáno v Cell Oncol (2008)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Autor Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
Vydáno v Front Oncol (2016)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

Autor Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
Vydáno v Front Oncol (2018)

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

Autor Synnott, Naoise C., Madden, Stephen F., Bykov, Vladimir J.N., Crown, John, Wiman, Klas G., Duffy, Michael J.
Vydáno v Transl Oncol (2018)

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

Autor Bykov, Vladimir J. N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
Vydáno v J Biol Chem (2017)

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Autor Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
Vydáno v Sci Rep (2018)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

Autor Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
Vydáno v Mol Oncol (2008)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

Autor Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
Vydáno v Mol Oncol (2017)

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

Autor Shen, Jinfeng, van den Bogaard, Ellen H., Kouwenhoven, Evelyn N., Bykov, Vladimir J. N., Rinne, Tuula, Zhang, Qiang, Tjabringa, Geuranne S., Gilissen, Christian, van Heeringen, Simon J., Schalkwijk, Joost, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing
Vydáno 2013

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

Autor Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
Vydáno v Cell Death Dis (2021)

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

Autor Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
Vydáno v EMBO Mol Med (2020)