APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

অনুযায়ী Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
প্রকাশিত Cell Death Dis (2018)

p53 as a hub in cellular redox regulation and therapeutic target in cancer

অনুযায়ী Eriksson, Sofi E, Ceder, Sophia, Bykov, Vladimir J N, Wiman, Klas G
প্রকাশিত J Mol Cell Biol (2019)

Correction: APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

অনুযায়ী Zhang, Qiang, Bykov, Vladimir J. N., Wiman, Klas G., Zawacka-Pankau, Joanna
প্রকাশিত Cell Death Dis (2019)

PRIMA-1(MET) Inhibits Growth of Mouse Tumors Carrying Mutant p53

অনুযায়ী Zache, Nicole, Lambert, Jeremy M. R., Wiman, Klas G., Bykov, Vladimir J. N.
প্রকাশিত Cell Oncol (2008)

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

অনুযায়ী Bykov, Vladimir J. N., Zhang, Qiang, Zhang, Meiqiongzi, Ceder, Sophia, Abrahmsen, Lars, Wiman, Klas G.
প্রকাশিত Front Oncol (2016)

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

অনুযায়ী Zhang, Meiqiongzi, Heldin, Angelos, Palomar-Siles, Mireia, Öhlin, Susanne, Bykov, Vladimir J. N., Wiman, Klas G.
প্রকাশিত Front Oncol (2018)

The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

অনুযায়ী Synnott, Naoise C., Madden, Stephen F., Bykov, Vladimir J.N., Crown, John, Wiman, Klas G., Duffy, Michael J.
প্রকাশিত Transl Oncol (2018)

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

অনুযায়ী Bykov, Vladimir J. N., Issaeva, Natalia, Zache, Nicole, Shilov, Alexandre, Hultcrantz, Monica, Bergman, Jan, Selivanova, Galina, Wiman, Klas G.
প্রকাশিত J Biol Chem (2017)

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

অনুযায়ী Haffo, Lena, Lu, Jun, Bykov, Vladimir J. N., Martin, Sebastin S., Ren, Xiaoyuan, Coppo, Lucia, Wiman, Klas G., Holmgren, Arne
প্রকাশিত Sci Rep (2018)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

অনুযায়ী Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
প্রকাশিত Mol Oncol (2008)

Mutant p53 targeting by the low molecular weight compound STIMA‐1

অনুযায়ী Zache, Nicole, Lambert, Jeremy M.R., Rökaeus, Nina, Shen, Jinfeng, Hainaut, Pierre, Bergman, Jan, Wiman, Klas G., Bykov, Vladimir J.N.
প্রকাশিত Mol Oncol (2017)

APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

অনুযায়ী Shen, Jinfeng, van den Bogaard, Ellen H., Kouwenhoven, Evelyn N., Bykov, Vladimir J. N., Rinne, Tuula, Zhang, Qiang, Tjabringa, Geuranne S., Gilissen, Christian, van Heeringen, Simon J., Schalkwijk, Joost, van Bokhoven, Hans, Wiman, Klas G., Zhou, Huiqing
প্রকাশিত 2013

Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

অনুযায়ী Ceder, Sophia, Eriksson, Sofi E., Liang, Ying Yu, Cheteh, Emarndeena H., Zhang, Si Min, Fujihara, Kenji M., Bianchi, Julie, Bykov, Vladimir J. N., Abrahmsen, Lars, Clemons, Nicholas J., Nordlund, Pär, Rudd, Sean G., Wiman, Klas G.
প্রকাশিত Cell Death Dis (2021)

A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death

অনুযায়ী Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G
প্রকাশিত EMBO Mol Med (2020)