Advances in Tau-focused drug discovery for Alzheimer's disease and related tauopathies

Por Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado em 2009

Evidence That Non-Fibrillar Tau Causes Pathology Linked To Neurodegeneration And Behavioral Impairments

Por Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M-Y.
Publicado em 2008

Characterization of tau fibrillization in vitro

Por Xu, Shaohua, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y.
Publicado em 2010

Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets

Por Lee, Virginia M-Y., Brunden, Kurt R., Hutton, Michael, Trojanowski, John Q.
Publicado em 2011

1,2,4-Triazolo[1,5-a]pyrimidines in Drug Design

Por Oukoloff, Killian, Lucero, Bobby, Francisco, Karol R., Brunden, Kurt R., Ballatore, Carlo
Publicado no Eur J Med Chem (2019)

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies

Por Brunden, Kurt R., Ballatore, Carlo, Lee, Virginia M.-Y., Smith, Amos B., Trojanowski, John Q.
Publicado em 2012

Microtubule-Stabilizing Agents as Potential Therapeutics for Neurodegenerative Disease

Por Brunden, Kurt R., Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo
Publicado em 2013

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497

Por Ballatore, Carlo, Smith, Amos B, Lee, Virginia M-Y, Trojanowski, John Q, Brunden, Kurt R
Publicado no Expert Opin Ther Pat (2014)

Therapeutic Strategies for the Treatment of Tauopathies: Hopes and Challenges

Por Khanna, Mansi R., Kovalevich, Jane, Lee, Virginia M-Y., Trojanowski, John Q., Brunden, Kurt R.
Publicado no Alzheimers Dement (2016)

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

Por Ballatore, Carlo, Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.
Publicado no ACS Chem Neurosci (2016)

Altered Microtubule Dynamics in Neurodegenerative Disease: Therapeutic Potential of Microtubule-Stabilizing Drugs

Por Brunden, Kurt R., Lee, Virginia M-Y., Smith, Amos B., Trojanowski, John Q., Ballatore, Carlo
Publicado no Neurobiol Dis (2016)

Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors

Por Herbst-Robinson, Katie J., Liu, Li, James, Michael, Yao, Yuemang, Xie, Sharon X., Brunden, Kurt R.
Publicado no Sci Rep (2015)

Tau-Directed Drug Discovery for Alzheimer’s Disease and Related Tauopathies: A Focus on Tau Assembly Inhibitors

Por Brunden, Kurt R., Ballatore, Carlo, Crowe, Alex, Smith, Amos B., Lee, Virginia M.-Y., Trojanowski, John Q.
Publicado em 2009

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Por Tanik, Selcuk A., Schultheiss, Christine E., Volpicelli-Daley, Laura A., Brunden, Kurt R., Lee, Virginia M. Y.
Publicado em 2013

Effects of TNFα-Converting Enzyme Inhibition on Amyloid β Production and APP Processing In Vitro and In Vivo

Por Kim, Minkyu L., Zhang, Bin, Mills, Ian P., Milla, Marcos E., Brunden, Kurt R., Lee, Virginia M.-Y.
Publicado em 2008

Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

Por Ballatore, Carlo, Brunden, Kurt R., Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.
Publicado em 2012

A model for improving the treatment and care of Alzheimer’s disease patients through interdisciplinary research

Por Trojanowski, John Q., Arnold, Steven E., Karlawish, Jason H., Naylor, Mary, Brunden, Kurt R., Lee, Virginia M.-Y.
Publicado em 2012

Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis

Por Monti, Ludovica, Wang, Steven C, Oukoloff, Killian, Smith, Amos B., Brunden, Kurt R., Caffrey, Conor R., Ballatore, Carlo
Publicado no ChemMedChem (2018)

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

Por Crowe, Alex, James, Michael J., Lee, Virginia M.-Y., Smith, Amos B., Trojanowski, John Q., Ballatore, Carlo, Brunden, Kurt R.
Publicado em 2013

Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Por Landreth, Gary E., Cramer, Paige E., Lakner, Mitchell M., Cirrito, John R., Wesson, Daniel W., Brunden, Kurt R., Wilson, Donald A.
Publicado em 2013