Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease. Activation of macroautophagy is suggested to facilitate degradation of certain proteinaceous inclusions, but it is unclear if...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tanik, Selcuk A., Schultheiss, Christine E., Volpicelli-Daley, Laura A., Brunden, Kurt R., Lee, Virginia M. Y.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663539/
https://ncbi.nlm.nih.gov/pubmed/23532841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457408
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