Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease. Activation of macroautophagy is suggested to facilitate degradation of certain proteinaceous inclusions, but it is unclear if...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Tanik, Selcuk A., Schultheiss, Christine E., Volpicelli-Daley, Laura A., Brunden, Kurt R., Lee, Virginia M. Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663539/
https://ncbi.nlm.nih.gov/pubmed/23532841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457408
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky