Presynaptic α-Synuclein Aggregates, Not Lewy Bodies, Cause Neurodegeneration in Dementia with Lewy Bodies

Lewy bodies, the pathological hallmark of dementia with Lewy bodies (DLB), are large juxtanuclear inclusions of aggregated α-synuclein. However, the small number of cortical Lewy bodies relative to the total neuron count does not correlate with the extent of cognitive impairment. In contrast to dopa...

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Vydáno v:J Neurosci
Hlavní autoři: Kramer, Michael L., Schulz-Schaeffer, Walter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2007
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673583/
https://ncbi.nlm.nih.gov/pubmed/17287515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4564-06.2007
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