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Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease. Activation of macroautophagy is suggested to facilitate degradation of certain proteinaceous inclusions, but it is unclear if...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663539/ https://ncbi.nlm.nih.gov/pubmed/23532841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.457408 |
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