Oncolytic Viruses: Therapeutics With an Identity Crisis

Por Breitbach, Caroline J., Lichty, Brian D., Bell, John C.
Publicado no EBioMedicine (2016)

The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594)

Por Breitbach, Caroline J, Bell, John C, Hwang, Tae-Ho, Kirn, David H, Burke, James
Publicado no Oncolytic Virother (2015)

Oncolytic Virotherapy as Emerging Immunotherapeutic Modality: Potential of Parvovirus H-1

Por Moehler, Markus, Goepfert, Katrin, Heinrich, Bernd, Breitbach, Caroline J., Delic, Maike, Galle, Peter Robert, Rommelaere, Jean
Publicado em 2014

Phase 1 Study of Intravenous Oncolytic Poxvirus (vvDD) in Patients With Advanced Solid Cancers

Por Downs-Canner, Stephanie, Guo, Zong Sheng, Ravindranathan, Roshni, Breitbach, Caroline J, O'Malley, Mark E, Jones, Heather L, Moon, Anne, McCart, Judith Andrea, Shuai, Yongli, Zeh, Herbert J, Bartlett, David L
Publicado no Mol Ther (2016)

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

Por Hwang, Tae-Ho, Moon, Anne, Burke, James, Ribas, Antoni, Stephenson, Joe, Breitbach, Caroline J, Daneshmand, Manijeh, De Silva, Naomi, Parato, Kelley, Diallo, Jean-Simon, Lee, Yeon-Sook, Liu, Ta-Chiang, Bell, John C, Kirn, David H
Publicado em 2011

Targeting Tumor Vasculature With an Oncolytic Virus

Por Breitbach, Caroline J, De Silva, Naomi S, Falls, Theresa J, Aladl, Usaf, Evgin, Laura, Paterson, Jennifer, Sun, Yang Yang, Roy, Dominic G, Rintoul, Julia L, Daneshmand, Manijeh, Parato, Kelley, Stanford, Marianne M, Lichty, Brian D, Fenster, Aaron, Kirn, David, Atkins, Harold, Bell, John C
Publicado em 2011

Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients

Por Cripe, Timothy P, Ngo, Minhtran C, Geller, James I, Louis, Chrystal U, Currier, Mark A, Racadio, John M, Towbin, Alexander J, Rooney, Cliona M, Pelusio, Adina, Moon, Anne, Hwang, Tae-Ho, Burke, James M, Bell, John C, Kirn, David H, Breitbach, Caroline J
Publicado no Mol Ther (2015)

Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer

Por Park, Se Hoon, Breitbach, Caroline J, Lee, Jeeyun, Park, Joon Oh, Lim, Ho Yeong, Kang, Won Ki, Moon, Anne, Mun, Jae-Hee, Sommermann, Erica M, Maruri Avidal, Liliana, Patt, Rick, Pelusio, Adina, Burke, James, Hwang, Tae-Ho, Kirn, David, Park, Young Suk
Publicado no Mol Ther (2015)

Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy

Por Heo, Jeong, Breitbach, Caroline J, Moon, Anne, Kim, Chang Won, Patt, Rick, Kim, Mi Kyung, Lee, Yu Kyung, Oh, Sung Yong, Woo, Hyun Young, Parato, Kelley, Rintoul, Julia, Falls, Theresa, Hickman, Theresa, Rhee, Byung-Geon, Bell, John C, Kirn, David H, Hwang, Tae-Ho
Publicado em 2011

The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

Por Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Laura, Hu, Kang, Paradis, Francois, Knowles, Shane, Hwang, Tae-Ho, Vanderhyden, Barbara C, Auer, Rebecca, Kirn, David H, Bell, John C
Publicado em 2012

First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity

Por Zeh, Herbert J, Downs-Canner, Stephanie, McCart, J Andrea, Guo, Zong Sheng, Rao, Uma N M, Ramalingam, Lekshmi, Thorne, Stephen H, Jones, Heather L, Kalinski, Pawel, Wieckowski, Eva, O'Malley, Mark E, Daneshmand, Manijeh, Hu, Kang, Bell, John C, Hwang, Tae-Ho, Moon, Anne, Breitbach, Caroline J, Kirn, David H, Bartlett, David L
Publicado no Mol Ther (2015)

Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques

Por Evgin, Laura, Acuna, Sergio A, Tanese de Souza, Christiano, Marguerie, Monique, Lemay, Chantal G, Ilkow, Carolina S, Findlay, C Scott, Falls, Theresa, Parato, Kelley A, Hanwell, David, Goldstein, Alyssa, Lopez, Roberto, Lafrance, Sandra, Breitbach, Caroline J, Kirn, David, Atkins, Harold, Auer, Rebecca C, Thurman, Joshua M, Stahl, Gregory L, Lambris, John D, Bell, John C, McCart, J Andrea
Publicado no Mol Ther (2015)

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Por Heo, Jeong, Reid, Tony, Ruo, Leyo, Breitbach, Caroline J, Rose, Steven, Bloomston, Mark, Cho, Mong, Lim, Ho Yeong, Chung, Hyun Cheol, Kim, Chang Won, Burke, James, Lencioni, Riccardo, Hickman, Theresa, Moon, Anne, Lee, Yeon Sook, Kim, Mi Kyeong, Daneshmand, Manijeh, Dubois, Kara, Longpre, Lara, Ngo, Minhtran, Rooney, Cliona, Bell, John C, Rhee, Byung-Geon, Patt, Richard, Hwang, Tae-Ho, Kirn, David H
Publicado no Nat Med (2013)