A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

JX-594 is a targeted and granulocyte macrophage-colony stimulating factor (GM-CSF)-expressing oncolytic poxvirus designed to selectively replicate in and destroy cancer cells through viral oncolysis and tumor-specific immunity. In order to study the mechanisms-of-action (MOA) of JX-594 in humans, a...

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Main Authors: Hwang, Tae-Ho, Moon, Anne, Burke, James, Ribas, Antoni, Stephenson, Joe, Breitbach, Caroline J, Daneshmand, Manijeh, De Silva, Naomi, Parato, Kelley, Diallo, Jean-Simon, Lee, Yeon-Sook, Liu, Ta-Chiang, Bell, John C, Kirn, David H
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2011
Ábhair:
Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188739/
https://ncbi.nlm.nih.gov/pubmed/21772252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.132
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