The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers

Oncolytic viruses are generally designed to be cancer selective on the basis of a single genetic mutation. JX-594 is a thymidine kinase (TK) gene-inactivated oncolytic vaccinia virus expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) and lac-Z transgenes that is designed to destroy...

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Main Authors: Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Laura, Hu, Kang, Paradis, Francois, Knowles, Shane, Hwang, Tae-Ho, Vanderhyden, Barbara C, Auer, Rebecca, Kirn, David H, Bell, John C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321594/
https://ncbi.nlm.nih.gov/pubmed/22186794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.276
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