Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques

Oncolytic viruses (OVs) have shown promising clinical activity when administered by direct intratumoral injection. However, natural barriers in the blood, including antibodies and complement, are likely to limit the ability to repeatedly administer OVs by the intravenous route. We demonstrate here t...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Evgin, Laura, Acuna, Sergio A, Tanese de Souza, Christiano, Marguerie, Monique, Lemay, Chantal G, Ilkow, Carolina S, Findlay, C Scott, Falls, Theresa, Parato, Kelley A, Hanwell, David, Goldstein, Alyssa, Lopez, Roberto, Lafrance, Sandra, Breitbach, Caroline J, Kirn, David, Atkins, Harold, Auer, Rebecca C, Thurman, Joshua M, Stahl, Gregory L, Lambris, John D, Bell, John C, McCart, J Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817751/
https://ncbi.nlm.nih.gov/pubmed/25807289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.49
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