Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques

Oncolytic viruses (OVs) have shown promising clinical activity when administered by direct intratumoral injection. However, natural barriers in the blood, including antibodies and complement, are likely to limit the ability to repeatedly administer OVs by the intravenous route. We demonstrate here t...

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Vydáno v:Mol Ther
Hlavní autoři: Evgin, Laura, Acuna, Sergio A, Tanese de Souza, Christiano, Marguerie, Monique, Lemay, Chantal G, Ilkow, Carolina S, Findlay, C Scott, Falls, Theresa, Parato, Kelley A, Hanwell, David, Goldstein, Alyssa, Lopez, Roberto, Lafrance, Sandra, Breitbach, Caroline J, Kirn, David, Atkins, Harold, Auer, Rebecca C, Thurman, Joshua M, Stahl, Gregory L, Lambris, John D, Bell, John C, McCart, J Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817751/
https://ncbi.nlm.nih.gov/pubmed/25807289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.49
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