First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor Activity

Oncolytic viral therapy utilizes a tumor-selective replicating virus which preferentially infects and destroys cancer cells and triggers antitumor immunity. The Western Reserve strain of vaccinia virus (VV) is the most virulent strain of VV in animal models and has been engineered for tumor selectiv...

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Detalles Bibliográficos
Publicado en:Mol Ther
Main Authors: Zeh, Herbert J, Downs-Canner, Stephanie, McCart, J Andrea, Guo, Zong Sheng, Rao, Uma N M, Ramalingam, Lekshmi, Thorne, Stephen H, Jones, Heather L, Kalinski, Pawel, Wieckowski, Eva, O'Malley, Mark E, Daneshmand, Manijeh, Hu, Kang, Bell, John C, Hwang, Tae-Ho, Moon, Anne, Breitbach, Caroline J, Kirn, David H, Bartlett, David L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426804/
https://ncbi.nlm.nih.gov/pubmed/25292189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.194
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