Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

著者: Farrell, Brendan, Breeze, Alexander L.
出版年 Biochem Soc Trans (2018)

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

著者: Klein, Tobias, Tucker, Julie, Holdgate, Geoffrey A., Norman, Richard A., Breeze, Alexander L.
出版事項 2013

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

著者: Teixeira, João M. C., Skinner, Simon P., Arbesú, Miguel, Breeze, Alexander L., Pons, Miquel
出版年 J Biomol NMR (2018)

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

著者: Sanfelice, Domenico, Koss, Hans, Bunney, Tom D., Thompson, Gary S., Farrell, Brendan, Katan, Matilda, Breeze, Alexander L.
出版年 Biomol NMR Assign (2018)

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by (1)H NMR Spectroscopy**

著者: Ma, Junhe, McLeod, Sarah, MacCormack, Kathleen, Sriram, Shubha, Gao, Ning, Breeze, Alexander L, Hu, Jun
出版年 Angew Chem Int Ed Engl (2014)

Target-Based Whole-Cell Screening by (1)H NMR Spectroscopy**

著者: Ma, Junhe, Cao, Qing, McLeod, Sarah M, Ferguson, Keith, Gao, Ning, Breeze, Alexander L, Hu, Jun
出版年 Angew Chem Int Ed Engl (2015)

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

著者: Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
出版年 J Biol Chem (2016)

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

著者: Smith, Hugh I., Guthertz, Nicolas, Cawood, Emma E., Maya-Martinez, Roberto, Breeze, Alexander L., Radford, Sheena E.
出版年 J Biol Chem (2020)

Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

著者: Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J
出版事項 2014

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

著者: Burslem, George M., Kyle, Hannah F., Breeze, Alexander L., Edwards, Thomas A., Nelson, Adam, Warriner, Stuart L., Wilson, Andrew J.
出版年 Chem Commun (Camb) (2016)

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

著者: Burslem, George M., Kyle, Hannah F., Prabhakaran, Panchami, Breeze, Alexander L., Edwards, Thomas A., Warriner, Stuart L., Nelson, Adam, Wilson, Andrew J.
出版年 Org Biomol Chem (2016)

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs

著者: dos Santos Rodrigues, Fabio Henrique, Firczuk, Helena, Breeze, Alexander L, Cameron, Alexander D, Walko, Martin, Wilson, Andrew J, Zanchin, Nilson I T, McCarthy, John E G
出版年 Nucleic Acids Res (2019)

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

著者: Bunney, Tom D., Inglis, Alison J., Sanfelice, Domenico, Farrell, Brendan, Kerr, Christopher J., Thompson, Gary S., Masson, Glenn R., Thiyagarajan, Nethaji, Svergun, Dmitri I., Williams, Roger L., Breeze, Alexander L., Katan, Matilda
出版年 Structure (2018)

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

著者: Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
出版年 Nat Commun (2015)

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

著者: Patani, Harshnira, Bunney, Tom D., Thiyagarajan, Nethaji, Norman, Richard A., Ogg, Derek, Breed, Jason, Ashford, Paul, Potterton, Andrew, Edwards, Mina, Williams, Sarah V., Thomson, Gary S., Pang, Camilla S.M., Knowles, Margaret A., Breeze, Alexander L., Orengo, Christine, Phillips, Chris, Katan, Matilda
出版年 Oncotarget (2016)

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

著者: Haza, Katarzyna Z., Martin, Heather L., Rao, Ajinkya, Turner, Amy L., Saunders, Sophie E., Petersen, Britta, Tiede, Christian, Tipping, Kevin, Tang, Anna A., Ajayi, Modupe, Taylor, Thomas, Harvey, Maia, Fishwick, Keri M., Adams, Thomas L., Gaule, Thembaninkosi G., Trinh, Chi H., Johnson, Matthew, Breeze, Alexander L., Edwards, Thomas A., McPherson, Michael J., Tomlinson, Darren C.
出版年 Nat Commun (2021)