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Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by (1)H NMR Spectroscopy**
Disconnections between in vitro responses and those observed in whole cells confound many attempts to design drugs in areas of serious medical need. A method based on 1D (1)H NMR spectroscopy is reported that affords the ability to monitor the hydrolytic decomposition of the carbapenem antibiotic me...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232273/ https://ncbi.nlm.nih.gov/pubmed/24458501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201308636 |
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