Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by (19)F NMR Spectroscopy**

The New Delhi metallo-β-lactamase (NDM-1) is involved in the emerging antibiotic resistance problem. Development of metallo-β-lactamases (MBLs) inhibitors has proven challenging, due to their conformational flexibility. Here we report site-selective labeling of NDM-1 with 1,1,1-trifluoro-3-bromo ace...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Rydzik, Anna M, Brem, Jürgen, van Berkel, Sander S, Pfeffer, Inga, Makena, Anne, Claridge, Timothy D W, Schofield, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499255/
https://ncbi.nlm.nih.gov/pubmed/24615874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201310866
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