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Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by (19)F NMR Spectroscopy**
The New Delhi metallo-β-lactamase (NDM-1) is involved in the emerging antibiotic resistance problem. Development of metallo-β-lactamases (MBLs) inhibitors has proven challenging, due to their conformational flexibility. Here we report site-selective labeling of NDM-1 with 1,1,1-trifluoro-3-bromo ace...
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| Veröffentlicht in: | Angew Chem Int Ed Engl |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
WILEY-VCH Verlag
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4499255/ https://ncbi.nlm.nih.gov/pubmed/24615874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201310866 |
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