(19)F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase

Resistance to β‐lactam antibiotics mediated by metallo‐β‐lactamases (MBLs) is a growing problem. We describe the use of protein‐observe (19)F‐NMR (PrOF NMR) to study the dynamics of the São Paulo MBL (SPM‐1) from β‐lactam‐resistant Pseudomonas aeruginosa. Cysteinyl variants on the α3 and L3 regions,...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Abboud, Martine I., Hinchliffe, Philip, Brem, Jürgen, Macsics, Robert, Pfeffer, Inga, Makena, Anne, Umland, Klaus‐Daniel, Rydzik, Anna M., Li, Guo‐Bo, Spencer, James, Claridge, Timothy D. W., Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396265/
https://ncbi.nlm.nih.gov/pubmed/28252254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201612185
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