Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibiotics. We report biophysical and kinetic studies on the São Paulo MBL (SPM-1), which reveal its Zn(ii) ion usage and mechanism as characteristic of the clinically important di-Zn(ii) dependent B1 MBL subfamily. Biophysi...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Chem Sci
Autori principali: Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Justin L. P., Schofield, Christopher J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2015
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333608/
https://ncbi.nlm.nih.gov/pubmed/25717359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01752h
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi