Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibiotics. We report biophysical and kinetic studies on the São Paulo MBL (SPM-1), which reveal its Zn(ii) ion usage and mechanism as characteristic of the clinically important di-Zn(ii) dependent B1 MBL subfamily. Biophysi...

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Spremljeno u:
Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Justin L. P., Schofield, Christopher J.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2015
Teme:
Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333608/
https://ncbi.nlm.nih.gov/pubmed/25717359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01752h
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