Cyclobutanone Mimics of Intermediates in Metallo‐β‐Lactamase Catalysis

The most important resistance mechanism to β‐lactam antibiotics involves hydrolysis by two β‐lactamase categories: the nucleophilic serine and the metallo‐β‐lactamases (SBLs and MBLs, respectively). Cyclobutanones are hydrolytically stable β‐lactam analogues with potential to inhibit both SBLs and M...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Abboud, Martine I., Kosmopoulou, Magda, Krismanich, Anthony P., Johnson, Jarrod W., Hinchliffe, Philip, Brem, Jürgen, Claridge, Timothy D. W., Spencer, James, Schofield, Christopher J., Dmitrienko, Gary I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947706/
https://ncbi.nlm.nih.gov/pubmed/29250863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201705886
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