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The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?
The D76N variant of human β(2)-microglobulin (β(2)m) is the causative agent of a hereditary amyloid disease. Interestingly, D76N-associated amyloidosis has a distinctive pathology compared with aggregation of WT-β(2)m, which occurs in dialysis-related amyloidosis. A folding intermediate of WT-β(2)m,...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7458819/ https://ncbi.nlm.nih.gov/pubmed/32661194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014901 |
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