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The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

The D76N variant of human β(2)-microglobulin (β(2)m) is the causative agent of a hereditary amyloid disease. Interestingly, D76N-associated amyloidosis has a distinctive pathology compared with aggregation of WT-β(2)m, which occurs in dialysis-related amyloidosis. A folding intermediate of WT-β(2)m,...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Smith, Hugh I., Guthertz, Nicolas, Cawood, Emma E., Maya-Martinez, Roberto, Breeze, Alexander L., Radford, Sheena E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458819/
https://ncbi.nlm.nih.gov/pubmed/32661194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014901
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