Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease. Here, using a combination of chemical kinetics, NMR spectroscopy and other biophysic...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Karamanos, Theodoros K, Jackson, Matthew P, Calabrese, Antonio N, Goodchild, Sophia C, Cawood, Emma E, Thompson, Gary S, Kalverda, Arnout P, Hewitt, Eric W, Radford, Sheena E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783270/
https://ncbi.nlm.nih.gov/pubmed/31552823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46574
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