Distinguishing Closely Related Amyloid Precursors Using an RNA Aptamer

Although amyloid fibrils assembled in vitro commonly involve a single protein, fibrils formed in vivo can contain multiple protein sequences. The amyloidogenic protein human β(2)-microglobulin (hβ(2)m) can co-polymerize with its N-terminally truncated variant (ΔN6) in vitro to form hetero-polymeric...

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Main Authors: Sarell, Claire J., Karamanos, Theodoros K., White, Simon J., Bunka, David H. J., Kalverda, Arnout P., Thompson, Gary S., Barker, Amy M., Stockley, Peter G., Radford, Sheena E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175327/
https://ncbi.nlm.nih.gov/pubmed/25100729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595066
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