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Visualizing and trapping transient oligomers in amyloid assembly pathways

Oligomers which form during amyloid fibril assembly are considered to be key contributors towards amyloid disease. However, understanding how such intermediates form, their structure, and mechanisms of toxicity presents significant challenges due to their transient and heterogeneous nature. Here, we...

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Detalhes bibliográficos
Publicado no:Biophys Chem
Main Authors: Cawood, Emma E., Karamanos, Theodoros K., Wilson, Andrew J., Radford, Sheena E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science B.V 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8188297/
https://ncbi.nlm.nih.gov/pubmed/33220582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2020.106505
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