Structural mapping of oligomeric intermediates in an amyloid assembly pathway

Transient oligomers are commonly formed in the early stages of amyloid assembly. Determining the structure(s) of these species and defining their role(s) in assembly is key to devising new routes to control disease. Here, using a combination of chemical kinetics, NMR spectroscopy and other biophysic...

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Publicat a:eLife
Autors principals: Karamanos, Theodoros K, Jackson, Matthew P, Calabrese, Antonio N, Goodchild, Sophia C, Cawood, Emma E, Thompson, Gary S, Kalverda, Arnout P, Hewitt, Eric W, Radford, Sheena E
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Structural Biology and Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783270/
https://ncbi.nlm.nih.gov/pubmed/31552823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46574
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