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A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity

[Image: see text] The balance between protein folding and misfolding is a crucial determinant of amyloid assembly. Transient intermediates that are sparsely populated during protein folding have been identified as key players in amyloid aggregation. However, due to their ephemeral nature, structural...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Am Chem Soc
Κύριοι συγγραφείς: Karamanos, Theodoros K., Pashley, Clare L., Kalverda, Arnout P., Thompson, Gary S., Mayzel, Maxim, Orekhov, Vladislav Y., Radford, Sheena E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2016
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922733/
https://ncbi.nlm.nih.gov/pubmed/27117876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02464
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