A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity

[Image: see text] The balance between protein folding and misfolding is a crucial determinant of amyloid assembly. Transient intermediates that are sparsely populated during protein folding have been identified as key players in amyloid aggregation. However, due to their ephemeral nature, structural...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Karamanos, Theodoros K., Pashley, Clare L., Kalverda, Arnout P., Thompson, Gary S., Mayzel, Maxim, Orekhov, Vladislav Y., Radford, Sheena E.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922733/
https://ncbi.nlm.nih.gov/pubmed/27117876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02464
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