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A Population Shift between Sparsely Populated Folding Intermediates Determines Amyloidogenicity
[Image: see text] The balance between protein folding and misfolding is a crucial determinant of amyloid assembly. Transient intermediates that are sparsely populated during protein folding have been identified as key players in amyloid aggregation. However, due to their ephemeral nature, structural...
Gardado en:
| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2016
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922733/ https://ncbi.nlm.nih.gov/pubmed/27117876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b02464 |
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