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Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

α-Helix proteomimetics represent an emerging class of ligands that can be used to inhibit an array of helix mediated protein–protein interactions. Within this class of inhibitor, aromatic oligobenzamide foldamers have been widely and successfully used. This manuscript describes alternative syntheses...

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Bibliographische Detailangaben
Veröffentlicht in:Org Biomol Chem
Hauptverfasser: Burslem, George M., Kyle, Hannah F., Prabhakaran, Panchami, Breeze, Alexander L., Edwards, Thomas A., Warriner, Stuart L., Nelson, Adam, Wilson, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839272/
https://ncbi.nlm.nih.gov/pubmed/27005701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00078a
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