Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

The therapeutically relevant hypoxia inducible factor HIF-1α–p300 protein–protein interaction can be orthosterically inhibited with α-helix mimetics based on an oligoamide scaffold that recapitulates essential features of the C-terminal helix of the HIF-1α C-TAD (C-terminal transactivation domain)....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159589/
https://ncbi.nlm.nih.gov/pubmed/24782431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201400009
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados