Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

द्वारा Farrell, Brendan, Breeze, Alexander L.
में प्रकाशित Biochem Soc Trans (2018)

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

द्वारा Klein, Tobias, Tucker, Julie, Holdgate, Geoffrey A., Norman, Richard A., Breeze, Alexander L.
प्रकाशित 2013

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

द्वारा Teixeira, João M. C., Skinner, Simon P., Arbesú, Miguel, Breeze, Alexander L., Pons, Miquel
में प्रकाशित J Biomol NMR (2018)

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

द्वारा Sanfelice, Domenico, Koss, Hans, Bunney, Tom D., Thompson, Gary S., Farrell, Brendan, Katan, Matilda, Breeze, Alexander L.
में प्रकाशित Biomol NMR Assign (2018)

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by (1)H NMR Spectroscopy**

द्वारा Ma, Junhe, McLeod, Sarah, MacCormack, Kathleen, Sriram, Shubha, Gao, Ning, Breeze, Alexander L, Hu, Jun
में प्रकाशित Angew Chem Int Ed Engl (2014)

Target-Based Whole-Cell Screening by (1)H NMR Spectroscopy**

द्वारा Ma, Junhe, Cao, Qing, McLeod, Sarah M, Ferguson, Keith, Gao, Ning, Breeze, Alexander L, Hu, Jun
में प्रकाशित Angew Chem Int Ed Engl (2015)

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

द्वारा Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
में प्रकाशित J Biol Chem (2016)

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

द्वारा Smith, Hugh I., Guthertz, Nicolas, Cawood, Emma E., Maya-Martinez, Roberto, Breeze, Alexander L., Radford, Sheena E.
में प्रकाशित J Biol Chem (2020)

Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

द्वारा Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J
प्रकाशित 2014

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

द्वारा Burslem, George M., Kyle, Hannah F., Breeze, Alexander L., Edwards, Thomas A., Nelson, Adam, Warriner, Stuart L., Wilson, Andrew J.
में प्रकाशित Chem Commun (Camb) (2016)

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

द्वारा Burslem, George M., Kyle, Hannah F., Prabhakaran, Panchami, Breeze, Alexander L., Edwards, Thomas A., Warriner, Stuart L., Nelson, Adam, Wilson, Andrew J.
में प्रकाशित Org Biomol Chem (2016)

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs

द्वारा dos Santos Rodrigues, Fabio Henrique, Firczuk, Helena, Breeze, Alexander L, Cameron, Alexander D, Walko, Martin, Wilson, Andrew J, Zanchin, Nilson I T, McCarthy, John E G
में प्रकाशित Nucleic Acids Res (2019)

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

द्वारा Bunney, Tom D., Inglis, Alison J., Sanfelice, Domenico, Farrell, Brendan, Kerr, Christopher J., Thompson, Gary S., Masson, Glenn R., Thiyagarajan, Nethaji, Svergun, Dmitri I., Williams, Roger L., Breeze, Alexander L., Katan, Matilda
में प्रकाशित Structure (2018)

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

द्वारा Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
में प्रकाशित Nat Commun (2015)

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

द्वारा Patani, Harshnira, Bunney, Tom D., Thiyagarajan, Nethaji, Norman, Richard A., Ogg, Derek, Breed, Jason, Ashford, Paul, Potterton, Andrew, Edwards, Mina, Williams, Sarah V., Thomson, Gary S., Pang, Camilla S.M., Knowles, Margaret A., Breeze, Alexander L., Orengo, Christine, Phillips, Chris, Katan, Matilda
में प्रकाशित Oncotarget (2016)

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

द्वारा Haza, Katarzyna Z., Martin, Heather L., Rao, Ajinkya, Turner, Amy L., Saunders, Sophie E., Petersen, Britta, Tiede, Christian, Tipping, Kevin, Tang, Anna A., Ajayi, Modupe, Taylor, Thomas, Harvey, Maia, Fishwick, Keri M., Adams, Thomas L., Gaule, Thembaninkosi G., Trinh, Chi H., Johnson, Matthew, Breeze, Alexander L., Edwards, Thomas A., McPherson, Michael J., Tomlinson, Darren C.
में प्रकाशित Nat Commun (2021)