Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

מאת Farrell, Brendan, Breeze, Alexander L.
הוצא לאור ב Biochem Soc Trans (2018)

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures

מאת Klein, Tobias, Tucker, Julie, Holdgate, Geoffrey A., Norman, Richard A., Breeze, Alexander L.
יצא לאור 2013

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

מאת Teixeira, João M. C., Skinner, Simon P., Arbesú, Miguel, Breeze, Alexander L., Pons, Miquel
הוצא לאור ב J Biomol NMR (2018)

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

מאת Sanfelice, Domenico, Koss, Hans, Bunney, Tom D., Thompson, Gary S., Farrell, Brendan, Katan, Matilda, Breeze, Alexander L.
הוצא לאור ב Biomol NMR Assign (2018)

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by (1)H NMR Spectroscopy**

מאת Ma, Junhe, McLeod, Sarah, MacCormack, Kathleen, Sriram, Shubha, Gao, Ning, Breeze, Alexander L, Hu, Jun
הוצא לאור ב Angew Chem Int Ed Engl (2014)

Target-Based Whole-Cell Screening by (1)H NMR Spectroscopy**

מאת Ma, Junhe, Cao, Qing, McLeod, Sarah M, Ferguson, Keith, Gao, Ning, Breeze, Alexander L, Hu, Jun
הוצא לאור ב Angew Chem Int Ed Engl (2015)

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

מאת Vo, Uybach, Vajpai, Navratna, Flavell, Liz, Bobby, Romel, Breeze, Alexander L., Embrey, Kevin J., Golovanov, Alexander P.
הוצא לאור ב J Biol Chem (2016)

The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

מאת Smith, Hugh I., Guthertz, Nicolas, Cawood, Emma E., Maya-Martinez, Roberto, Breeze, Alexander L., Radford, Sheena E.
הוצא לאור ב J Biol Chem (2020)

Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

מאת Burslem, George M, Kyle, Hannah F, Breeze, Alexander L, Edwards, Thomas A, Nelson, Adam, Warriner, Stuart L, Wilson, Andrew J
יצא לאור 2014

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

מאת Burslem, George M., Kyle, Hannah F., Breeze, Alexander L., Edwards, Thomas A., Nelson, Adam, Warriner, Stuart L., Wilson, Andrew J.
הוצא לאור ב Chem Commun (Camb) (2016)

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

מאת Burslem, George M., Kyle, Hannah F., Prabhakaran, Panchami, Breeze, Alexander L., Edwards, Thomas A., Warriner, Stuart L., Nelson, Adam, Wilson, Andrew J.
הוצא לאור ב Org Biomol Chem (2016)

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs

מאת dos Santos Rodrigues, Fabio Henrique, Firczuk, Helena, Breeze, Alexander L, Cameron, Alexander D, Walko, Martin, Wilson, Andrew J, Zanchin, Nilson I T, McCarthy, John E G
הוצא לאור ב Nucleic Acids Res (2019)

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

מאת Bunney, Tom D., Inglis, Alison J., Sanfelice, Domenico, Farrell, Brendan, Kerr, Christopher J., Thompson, Gary S., Masson, Glenn R., Thiyagarajan, Nethaji, Svergun, Dmitri I., Williams, Roger L., Breeze, Alexander L., Katan, Matilda
הוצא לאור ב Structure (2018)

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

מאת Klein, Tobias, Vajpai, Navratna, Phillips, Jonathan J., Davies, Gareth, Holdgate, Geoffrey A., Phillips, Chris, Tucker, Julie A., Norman, Richard A., Scott, Andrew D., Higazi, Daniel R., Lowe, David, Thompson, Gary S., Breeze, Alexander L.
הוצא לאור ב Nat Commun (2015)

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

מאת Patani, Harshnira, Bunney, Tom D., Thiyagarajan, Nethaji, Norman, Richard A., Ogg, Derek, Breed, Jason, Ashford, Paul, Potterton, Andrew, Edwards, Mina, Williams, Sarah V., Thomson, Gary S., Pang, Camilla S.M., Knowles, Margaret A., Breeze, Alexander L., Orengo, Christine, Phillips, Chris, Katan, Matilda
הוצא לאור ב Oncotarget (2016)

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

מאת Haza, Katarzyna Z., Martin, Heather L., Rao, Ajinkya, Turner, Amy L., Saunders, Sophie E., Petersen, Britta, Tiede, Christian, Tipping, Kevin, Tang, Anna A., Ajayi, Modupe, Taylor, Thomas, Harvey, Maia, Fishwick, Keri M., Adams, Thomas L., Gaule, Thembaninkosi G., Trinh, Chi H., Johnson, Matthew, Breeze, Alexander L., Edwards, Thomas A., McPherson, Michael J., Tomlinson, Darren C.
הוצא לאור ב Nat Commun (2021)