Double Trouble: Kinase domain duplication as a new path to drug resistance

per Chen, Hsin-Yi, Brady, Donita C., Villanueva, Jessie
Publicat a Pigment Cell Melanoma Res (2016)

Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer

per Blockhuys, Stéphanie, Brady, Donita C., Wittung-Stafshede, Pernilla
Publicat a Breast Cancer (2020)

ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis

per O'Hayer, Kevin M., Brady, Donita C., Counter, Christopher M.
Publicat 2009

Copper Chelation Inhibits BRAF(V600E)-driven Melanomagenesis and Counters Resistance to BRAF(V600E) and MEK1/2 Inhibitors

per Brady, Donita C., Crowe, Matthew S., Greenberg, Danielle N., Counter, Christopher M.
Publicat a Cancer Res (2017)

The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis

per Brady, Donita C., Alan, Jamie K., Madigan, James P., Fanning, Alan S., Cox, Adrienne D.
Publicat 2009

Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAF(V600E)-driven melanoma

per Kim, Ye-Jin, Tsang, Tiffany, Anderson, Grace R., Posimo, Jessica M., Brady, Donita C.
Publicat a Cancer Res (2020)

Copper chaperone ATOX1 is required for MAPK signaling and growth in BRAF mutation-positive melanoma

per Kim, Ye-Jin, Bond, Gavin J., Tsang, Tiffany, Posimo, Jessica M., Busino, Luca, Brady, Donita C.
Publicat a Metallomics (2019)

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

per Tsang, Tiffany, Posimo, Jessica M., Gudiel, Andrea A., Cicchini, Michelle, Feldser, David M., Brady, Donita C.
Publicat a Nat Cell Biol (2020)

Altered copper homeostasis underlies sensitivity of hepatocellular carcinoma to copper chelation

per Davis, Caroline I., Gu, Xingxing, Kiefer, Ryan M., Ralle, Martina, Gade, Terence P., Brady, Donita C.
Publicat a Metallomics (2020)

Ral activation promotes melanomagenesis

per Zipfel, Patty A., Brady, Donita C., Kashatus, David F., Ancrile, Brooke D., Tyler, Douglas S., Counter, Christopher M.
Publicat 2010

RalA and RalBP1 regulate mitochondrial fission at mitosis

per Kashatus, David F., Lim, Kian-Huat, Brady, Donita C., Pershing, Nicole L.K., Cox, Adrienne D., Counter, Christopher M.
Publicat 2011

Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

per Sadeghi, Rochelle Shirin, Kulej, Katarzyna, Kathayat, Rahul Singh, Garcia, Benjamin A, Dickinson, Bryan C, Brady, Donita C, Witze, Eric S
Publicat a eLife (2018)

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

per Chung, Clive Yik-Sham, Posimo, Jessica M., Lee, Sumin, Tsang, Tiffany, Davis, Julianne M., Brady, Donita C., Chang, Christopher J.
Publicat a Proc Natl Acad Sci U S A (2019)

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

per Lim, Kian-Huat, Brady, Donita C., Kashatus, David F., Ancrile, Brooke B., Der, Channing J., Cox, Adrienne D., Counter, Christopher M.
Publicat 2010

A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling

per Turski, Michelle L., Brady, Donita C., Kim, Hyung J., Kim, Byung-Eun, Nose, Yasuhiro, Counter, Christopher M., Winge, Dennis R., Thiele, Dennis J.
Publicat 2012

Copper is required for oncogenic BRAF signaling and tumorigenesis

per Brady, Donita C., Crowe, Matthew S., Turski, Michelle L., Hobbs, G. Aaron, Yao, Xiaojie, Chaikuad, Apirat, Knapp, Stefan, Xiao, Kunhong, Campbell, Sharon L., Thiele, Dennis J., Counter, Christopher M.
Publicat 2014

Regulation of Rnd3 Localization and Function By PKCα-Mediated Phosphorylation

per Madigan, James P., Bodemann, Brian O., Brady, Donita C., Dewar, Brian J., Keller, Patricia J., Leitges, Michael, Philips, Mark R., Ridley, Anne J., Der, Channing J., Cox, Adrienne D.
Publicat 2009

Combined menin and EGFR inhibitors synergize to suppress colorectal cancer via EGFR-independent and calcium-mediated repression of SKP2 transcription

per Katona, Bryson W., Glynn, Rebecca A., Paulosky, Kayla E., Feng, Zijie, Davis, Caroline I., Ma, Jian, Berry, Corbett T., Szigety, Katherine M., Matkar, Smita, Liu, Yuanyuan, Wang, Haoren, Wu, Yuan, He, Xin, Freedman, Bruce D., Brady, Donita C., Hua, Xianxin
Publicat a Cancer Res (2019)

CDK7 inhibition suppresses Castration-Resistant Prostate Cancer through MED1 inactivation

per ur Rasool, Reyaz, Natesan, Ramakrishnan, Deng, Qu, Aras, Shweta, Lal, Priti, Sander Effron, Samuel, Mitchell-Velasquez, Erick, Posimo, Jessica M., Carskadon, Shannon, Baca, Sylvan C., Pomerantz, Mark M., Siddiqui, Javed, Schwartz, Lauren E., Lee, Daniel J., Palanisamy, Nallasivam, Narla, Goutham, Den, Robert B., Freedman, Matthew L., Brady, Donita C., Asangani, Irfan A.
Publicat a Cancer Discov (2019)

A unified approach to targeting the lysosome’s degradative and growth signaling roles

per Rebecca, Vito W., Nicastri, Michael C., McLaughlin, Noel, Fennelly, Colin, McAfee, Quentin, Ronghe, Amruta, Nofal, Michel, Lim, Chun-Yan, Witze, Eric, Chude, Cynthia I., Zhang, Gao, Alicea, Gretchen M., Piao, Shengfu, Murugan, Sengottuvelan, Ojha, Rani, Levi, Samuel M., Wei, Zhi, Barber-Rotenberg, Julie S., Murphy, Maureen E., Mills, Gordon B., Lu, Yiling, Rabinowitz, Joshua, Marmorstein, Ronen, Liu, Qin, Liu, Shujing, Xu, Xiaowei, Herlyn, Meenhard, Zoncu, Roberto, Brady, Donita C., Speicher, David W., Winkler, Jeffrey D., Amaravadi, Ravi K.
Publicat a Cancer Discov (2017)