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Copper Chelation Inhibits BRAF(V600E)-driven Melanomagenesis and Counters Resistance to BRAF(V600E) and MEK1/2 Inhibitors
MEK1/2 and BRAF(V600E) inhibitors are used to treat BRAF(V600E)-positive melanoma, with other cancers under evaluation. Genetic perturbation of copper import or pharmacological reduction of copper with the clinical copper chelator TTM inhibits MEK1/2 kinase activity and reduces BRAF(V600E)-driven tu...
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| Pubblicato in: | Cancer Res |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5690876/ https://ncbi.nlm.nih.gov/pubmed/28986383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1190 |
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